Background parenchymal enhancement over exam time in patients with and without breast cancer
| Autor: | Yiming Gao, James S. Babb, Anjali Gudi, Akshat C. Pujara, Kristin Elias, Kristine Pysarenko, Amy N. Melsaether, Linda Moy, Katerina Dodelzon |
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| Rok vydání: | 2016 |
| Předmět: |
medicine.medical_specialty
medicine.diagnostic_test business.industry Health Insurance Portability and Accountability Act Breast magnetic resonance imaging Evidence-based medicine Institutional review board medicine.disease 030218 nuclear medicine & medical imaging Surgery 03 medical and health sciences 0302 clinical medicine Breast cancer McNemar's test 030220 oncology & carcinogenesis Medicine Breast MRI Radiology Nuclear Medicine and imaging In patient Radiology business |
| Zdroj: | Journal of Magnetic Resonance Imaging. 45:74-83 |
| ISSN: | 1053-1807 |
| Popis: | Purpose To compare background parenchymal enhancement (BPE) over time in patients with and without breast cancer. Materials and methods This retrospective Institutional Review Board (IRB)-approved, Health Insurance Portability and Accountability Act (HIPAA)-compliant study included 116 women (25-84 years, mean 54 years) with breast cancer who underwent breast magnetic resonance imaging at 3T between 1/2/2009 and 12/29/2009 and 116 age and date-of-exam-matched women without breast cancer (23-84 years, mean 51 years). Two independent, blinded readers (R1, R2) recorded BPE (minimal, mild, moderate, marked) at three times (100, 210, and 320 seconds postcontrast). Subsequent cancers were diagnosed in 9/96 control patients with follow up (12.6-93.0 months, mean 63.6 months). Exact Mann-Whitney, Fisher's exact, and McNemar tests were performed. Results Mean BPE was not found to be different between patients with and without breast cancer at any time (P = 0.36-0.64). At time 2 as compared with time 1, there were significantly more patients, both with and without breast cancer, with BPE >minimal (R1: 90 vs. 41 [P mild (R1: 59 vs. 10 [P mild at time 2. Conclusion BPE changes between the first and second postcontrast scans and stabilizes thereafter in most patients. Further investigation into the most clinically relevant timepoint for BPE assessment is warranted. Level of evidence 3 J. Magn. Reson. Imaging 2017;45:74-83. |
| Databáze: | OpenAIRE |
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