4,5-Dialkyl-substituted 3-oxo-(2H)-isothiazole 1,1-dioxides in reactions with diazomethane

Autor:	Vs. V. Nikolaev, D. B. Gidon, Ludmila L. Rodina, B. Shulze
Rok vydání:	2008
Předmět:	chemistry.chemical_classification Isothiazole Double bond Diazomethane Organic Chemistry Regioselectivity Methylation Alkylation Carbonyl group Medicinal chemistry Cycloaddition chemistry.chemical_compound chemistry Organic chemistry
Zdroj:	Chemistry of Heterocyclic Compounds. 44:466-473
ISSN:	1573-8353 0009-3122
Popis:	It has been established that the interaction of diazomethane with 4,5-dialkyl-substituted 3-oxo-(2H)-isothiazole 1,1-dioxides proceeds in two stages. Initially alkylation of the sulfonimide nitrogen atom and the carbonyl group oxygen atom occurs (in a ratio of ∼ 3:2), then there is a regioselective cycloaddition of diazomethane at the C=C double bond with the formation of the corresponding N-methyloxoisothiazolopyrazolines and 3-methoxyisothiazolopyrazolines.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::9690ad879220fe622f5dfafb6b70c346 https://doi.org/10.1007/s10593-008-0065-x Zobrazit plný text záznamu Plný text ve formátu PDF