Assignment of the 1H 500 MHz n.m.r. spectra of a synthetic eight-membered ring analogue of somatostatin in aqueous solution
| Autor: | C. Wynants, J. Zanen, A. Michel, Georges Van Binst |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Quantitative Biology::Biomolecules
Aqueous solution Nuclear magnetic resonance spectroscopy Ring (chemistry) Biochemistry Homonuclear molecule Ring size chemistry.chemical_compound Crystallography Nuclear magnetic resonance Somatostatin chemistry Amide Two-dimensional nuclear magnetic resonance spectroscopy |
| Zdroj: | International Journal of Peptide and Protein Research. 26:561-567 |
| ISSN: | 0367-8377 |
| Popis: | A somatostatin octapeptide analogue has been synthesized and its conformational properties have been studied by high field n.m.r. in water. All the proton signals of the individual amino acids have been assigned except for the aromatic protons, by use of 2D homonuclear correlation spectroscopy. Neither temperature effects on the amide protons nor the values of the coupling constants provided any significant arguments for predominant conformations. As in the case of somatostatin itself, analogues with this ring size remain very flexible. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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