| Autor: |
Jaime K. Knoch, Jason P. Lerch, Yuliya S. Nikolova, Dwight F. Newton, Amy Miles, Keith A. Misquitta, Mounira Banasr, Jacob Ellegood, Thomas D. Prevot, Etienne Sibille, Corey Fee |
| Rok vydání: |
2020 |
| Předmět: |
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| DOI: |
10.1101/2020.08.31.275750 |
| Popis: |
Clinical and preclinical studies report that chronic stress induces behavioral deficits as well as volumetric and synaptic alterations in corticolimbic brain regions including the anterior cingulate cortex (ACC), amygdala (AMY), nucleus accumbens (NAc) and hippocampus (HPC). Here, we aimed to investigate the volumetric changes associated with chronic restraint stress (CRS) and link these changes to the CRS-induced behavioral and synaptic deficits. We first confirmed that CRS increases behavioral emotionality, defined as collective scoring of anxiety- and anhedonia-like behaviors. We then demonstrated that CRS induced a reduction of total brain volume which negatively correlated with behavioral emotionality. Region-specific analysis identified that only the ACC showed significant decrease in volume following CRS (pHighlightsChronic restraint stress (CRS) decreases anterior cingulate cortex (ACC) volumeACC and amygdala (AMY) volumes negatively correlate with behavioral emotionalityCRS decreased the strength and degree of the ACC structural covariance networkCRS increased the strength and degree of the AMY structural covariance networkPSD95 puncta density correlates with behavioral emotionality and ACC volume. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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