Two new compounds and α-glucosidase inhibitors from the leaves of Bidens pilosa L
| Autor: | Truong Van Nguyen Thien, Nhan Trong Tran, Loan Kieu Thi Vo, Vi Ha Thi Huynh, Thuat My Luong, Toan Phan Duc, Tho Huu Le, Quang Ton That |
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| Rok vydání: | 2017 |
| Předmět: |
Chloroform
Aqueous solution biology 010405 organic chemistry Chemistry Stereochemistry α glucosidase Plant Science Asteraceae biology.organism_classification 01 natural sciences Biochemistry In vitro 0104 chemical sciences 010404 medicinal & biomolecular chemistry chemistry.chemical_compound Caffeoylquinic acid Bidens pilosa Ic50 values Agronomy and Crop Science Biotechnology |
| Zdroj: | Phytochemistry Letters. 20:119-122 |
| ISSN: | 1874-3900 |
| DOI: | 10.1016/j.phytol.2017.04.015 |
| Popis: | From the leaves of Bidens pilosa L., the n-hexane, chloroform, and aqueous extracts exhibited in vitro α-glucosidase inhibitory activity, with IC50 values of 235.8, 125.6, and 100.3 μg/mL, respectively. Two new compounds, methyl 4-O-caffeoyl-2-C-methyl- d -erythronate (1) and 4-O-methylokanin (2), and seven known compounds were isolated from these extracts. The chemical structures of 1–9 were elucidated on the basis of NMR spectroscopic analysis. The caffeoylquinic acid derivatives were isolated from the aqueous extract, and showed significant α-glucosidase inhibitory activity with IC50 values ranging from 10.7 to 74.7 μM. |
| Databáze: | OpenAIRE |
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