| Autor: | Vashchenko , Larisa N., Kozlova , Larisa S., Nikolaeva , Nadezhda V., Rozenko , Lyudmila Ya., Франциянц , Elena M., Barashev , Artem A., Vereskunova , Marina I., Shatova , Yuliana S. |
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| Jazyk: | ruština |
| Rok vydání: | 2017 |
| Předmět: | |
| DOI: | 10.23683/0321-3005-2017-3-2-58-66 |
| Popis: | Aim - studying the kinin-kallikrein system (KKS), trypsin-like proteases and universal blood plasma inhibitors in solitary osteolytic metastases from various primary tumors. Methods. We studied the citrated blood plasma of 30 patients aged 38–72 years with solitary osteolytic metastases (рT3-4NхM1) and of 32 donors: before surgery, after it (on days 1 and 7) and long after the discharge (in 1 and 6 months). Statistics: the STATISTICA 10.0. Results. Activity of kallikrein (K) before the treatment was increased sharply compared to the normal values, while prekallikrein (PK) levels were decreased, without significant changes during the observation period. Activity of carboxypeptidase N was 2.7 times lower than the norm; it continued decreasing on day 1, and then it started increasing, without reaching the normal levels. Total activity of trypsin-like proteases in the blood plasma before the treatment exceeded the norm by 3.4 times and maintained its high level during the entire observation period. Activity of α2M before the treatment was decreased by 2 times, compared to the norm, and maintained its low level after the surgery with a gradual increase by the end of observation. α1PI was lower than the norm by 1.9 times before treat-ment and was low during the observation period. Conclusions. In osteolytic metastasis from various primary tumors, the long-term activation of the KKS leads to the depletion of PK in the blood plasma, maintenance of high kallikrein activity, with decreasing activity of the carboxypeptidase kinin-destroying enzyme and universal α2M and α1PI inhibitors. The kinin system and universal α2M and α1PI inhibitors are the direct participants of the process of osteolytic metastasis formation. |
| Databáze: | OpenAIRE |
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