Synthesis and anticancer effects of pongamol derivatives on mitogen signaling and cell cycle kinases

Autor:	J. Madhusudana Rao, Amere Subbarao Sreedhar, Patnam Sreekanth, K. Suresh Babu, P. Prabhakar Reddy, Vishal Chaturvedi, V. Rama Subba Rao, R. Ranga Rao
Rok vydání:	2011
Předmět:	biology Stereochemistry Organic Chemistry Pyrazole Cell cycle biology.organism_classification Jurkat cells HeLa chemistry.chemical_compound Biochemistry chemistry Cell culture Mitogen-activated protein kinase biology.protein General Pharmacology Toxicology and Pharmaceutics Cytotoxicity Oxazole
Zdroj:	Medicinal Chemistry Research. 21:634-641
ISSN:	1554-8120 1054-2523
Popis:	A series of oxazole and pyrazole derivatives of pongamol (1) were designed and synthesized to examine their anti-cancer activity. The cytotoxicity of these compounds was examined in three different human tumor cell lines, IMR-32, HeLa and Jurkat. Although all compounds tested were quite effective than the pongamol against all the three different types of cancer cell lines examined, the compounds (2), (5), and (6) were found to be the most active compounds of this series. A series of pongamol derivatives (2–13) (oxazole and Pyrazole derivatives) have been synthesized and tested for their anti-cancer properties against the three human tumor cell lines (IMR32, HeLa, and jurkat).
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::96768a9944be3afe709ac94e1ce2eefb https://doi.org/10.1007/s00044-011-9563-y Zobrazit plný text záznamu Full text from SpringerLink