Supramolecular hydrogel of non-steroidal anti-inflammatory drugs: preparation, characterization and ocular biocompatibility
| Autor: | Xingyi Li, Shuai Shi, Zhifen He, Hao Chen, Guojuan Pu, Jing Yu, Wenguang Zhao, Zichao Luo, Xinxin Yu |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
Naproxen
Biocompatibility Stereochemistry medicine.drug_class Chemistry General Chemical Engineering technology industry and agriculture Supramolecular chemistry macromolecular substances 02 engineering and technology General Chemistry 010402 general chemistry 021001 nanoscience & nanotechnology Ibuprofen 01 natural sciences Combinatorial chemistry Anti-inflammatory 0104 chemical sciences In vivo Nanofiber Self-healing hydrogels medicine 0210 nano-technology medicine.drug |
| Zdroj: | RSC Advances. 6:62434-62438 |
| ISSN: | 2046-2069 |
| DOI: | 10.1039/c6ra09615h |
| Popis: | A supramolecular hydrogel based on a peptide (GFFY) and non-steroidal anti-inflammatory drugs (naproxen and ibuprofen) was synthesized for use as a topical gel. Using a heating–cooling strategy, the drug–peptide derivatives could self-assemble into nanofibers in aqueous solution to produce a supramolecular hydrogel. The different drug molecules used as the capping group had a profound effect on the self-assembly behaviour measured by circular dichroism. The supramolecular hydrogels were confirmed by rheological measurements to be thixotropic and had no apparent toxicity in vitro against HCEC and L-929 cells after 24 h incubation. More importantly, an in vivo ocular biocompatibility test indicated that the supramolecular hydrogels were well tolerated in rabbits and had satisfactory ocular biocompatibility, suggesting that they are promising candidates for the delivery of ocular drugs. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|