| Autor: |
Morimoto Yasunori, Iwao Nozawa, Yosuke Suzuki, Sugibayashi Kenji, Shuji Sato |
| Rok vydání: |
1991 |
| Předmět: |
|
| Zdroj: |
Journal of Controlled Release. 15:29-37 |
| ISSN: |
0168-3659 |
| DOI: |
10.1016/0168-3659(91)90100-r |
| Popis: |
A thermo-responsive membrane was incorporated into a transdermal therapeutic system (TTS) which responds to thermal stimuli associated with skin temperature changes. The thermo-responsive membrane was prepared by pouring monooxyethylene trimethylolpropane tristearate (MTTS) between two porous polypropylene films. The TTS with this thermoresponsive membrane as a rate controlling membrane released non-steroidal anti-inflammatory drugs (indomethacin, ketoprofen) and antipyretic drugs (acetoaminophen, ethenzamide) in response to temperature changes between 32 and 38°C in the in vitro experiments. It was then shown that the temperature-activated TTS was operative in vivo in a rabbit model . |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
|
