Prognostic performance of serial in-hospital measurements of copeptin and multiple novel biomarkers among patients with worsening heart failure: results from the MOLITOR study

Autor: Wolfram Doehner, Lindy Musial Bright, Sara Radenovic, Almuth Marx, Hans-Dirk Düngen, Mitja Lainscak, Goran Loncar, Frank Edelmann, Natasa Cvetinovic, Stephan von Haehling, Elvis Tahirovic, Svetlana Apostolović, Simone Inkrot, Danilo Obradovic, Djawid Hashemi, Tobias Daniel Trippel, Verena Tscholl, Burkert Pieske, Dragan Matic, Jovan Veskovic
Rok vydání: 2018
Předmět:
Zdroj: ESC Heart Failure. 5:288-296
ISSN: 2055-5822
DOI: 10.1002/ehf2.12231
Popis: AIMS In heart failure, various biomarkers are established for diagnosis and risk stratification; however, little is known about the relevance of serial measurements during an episode worsening heart failure (WHF). This study sought to investigate the trajectory of natriuretic peptides and multiple novel biomarkers during hospitalization for WHF and to determine the best time point to predict outcome. METHODS AND RESULTS MOLITOR (Impact of Therapy Optimisation on the Level of Biomarkers in Patients with Acute and Decompensated Chronic Heart Failure) was an eight-centre prospective study of 164 patients hospitalized with a primary diagnosis of WHF. C-terminal fragment of pre-pro-vasopressin (copeptin), N-terminal pro-B-type natriuretic peptide (NT-proBNP), mid-regional pro-atrial natriuretic peptide (MR-proANP), mid-regional pro-adrenomedullin (MR-proADM), and C-terminal pro-endothelin-1 (CT-proET1) were measured on admission, after 24, 48, and 72 h, and every 72 h thereafter, at discharge and follow-up visits. Their performance to predict all-cause mortality and rehospitalization at 90 days was compared. All biomarkers decreased during recompensation (P
Databáze: OpenAIRE
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