Association between the methylation status of PCDH17 and the efficacy of neoadjuvant chemotherapy in triple-negative breast cancer

Autor:	Shi-bing Wang, De-di Kong, Liang Li, Wei Wang, Rongzhan Fu
Rok vydání:	2020
Předmět:	Oncology Cancer Research medicine.medical_specialty Univariate analysis business.industry H&E stain Cancer Methylation medicine.disease Breast cancer Internal medicine Progesterone receptor medicine Epigenetics business Triple-negative breast cancer
Zdroj:	Oncology Letters. 20:1649-1656
ISSN:	1792-1082 1792-1074
Popis:	The present study aimed to assess whether the methylation status of the protocadherin 17 gene (PCDH17) in triple-negative breast cancer (TNBC) tissues was associated with the efficacy of neoadjuvant chemotherapy (NAC). The present study included 280 patients diagnosed with TNBC using core needle biopsy. Tumor pathological diagnosis was determined via hematoxylin and eosin staining. Immunohistochemical staining was used to determine estrogen receptor, progesterone receptor, human epidermal growth factor receptor-2 and Ki-67 status. PCDH17 methylation status was analyzed using methylation-specific PCR. χ2 tests were performed to analyze differences between PCDH17 methylation status and TNBC clinicopathological features. Univariate and multivariate logistic regressions were used to analyze whether PCDH17 methylation status predicted a curative effect of NAC. The multivariate analysis included factors with P
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::96677f82703b3009b360ba9f502a356d https://doi.org/10.3892/ol.2020.11737 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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