An integrated strategy for the discovery of drug targets by the analysis of protein–protein interactions
| Autor: | Mike Pyne, Paul B. Robbins, Robert R. Becklin, Kartika Widjaja, Shuping Lai, Sam Thompson, Lawrence Weir, J. Jay Boniface, Yew-Seng J. Ho, John M. Peltier, Moritz von Rechenberg, Cindy Lou Chepanoske, Peter J. Sheffield, Srdjan Askovic, Yuejun Zhen, Justin Savage, Vladimir Kery, Bonnie Richardson, Nafei Xu, Tahmina Mujtaba |
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| Rok vydání: | 2004 |
| Předmět: |
Drug
Reverse pharmacology Chemistry Drug discovery Process (engineering) media_common.quotation_subject Druggability Context (language use) Computational biology Condensed Matter Physics Proteomics Combinatorial chemistry Protein–protein interaction Physical and Theoretical Chemistry Instrumentation Spectroscopy media_common |
| Zdroj: | International Journal of Mass Spectrometry. 238:119-130 |
| ISSN: | 1387-3806 |
| Popis: | Proteomics-based technologies have the potential to accelerate the development of drugs, but such technologies must be well integrated in order to have a positive impact. We describe, herein, a multi-step process for the discovery of protein–protein interactions. It is shown that process stages are interdependent and can influence, either positively or negatively, subsequent steps. Optimization of each step, in the context of the full process, is essential for the overall success of the experiment. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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