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preterm birth 34 and 37 weeks for women with a history of LEEP. Patients with time intervals of 12 months vs. 12 months from LEEP to pregnancy were compared to identify crude odds ratios (OR) and adjusted OR for SAB and preterm birth. RESULTS: For 596 women with history of a LEEP, the median time to pregnancy was 30.8 (2.0-147.1) months. For women whose pregnancy ended in SAB, their time from LEEP to pregnancy was significantly shorter than those who did not have an SAB (20.3 months, range 3.4-89 vs. 31.2 months, range 2-147.1, p-value 0.01). However, there was no difference in time interval for women with a term birth compared to women with a preterm birth. In women with a time interval of 12 months compared to 12 months from LEEP to pregnancy, there was a significantly increased risk for SAB (17.9% vs. 4.6%, aOR 5.6, 95%CI 2.5-12.7). No increased risk was identified between the two groups for preterm birth 34 or 37 weeks (Table). CONCLUSION: Women with a shorter time interval from LEEP to pregnancy have an increased risk for SAB, but not preterm birth. When pregnancy occurs within 12 months of LEEP, there is greater than a 5-fold increased risk of pregnancy loss prior to 12 weeks. |
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