Detection of Amyloid Beta Fibril Growth by Liposome-Immobilized Micro-Cantilever With NiCr Thin-Film Strain Gauge

Autor:	Kaoru Yamashita, Z. Zhang, Toshio Akai, Masayuki Sohgawa, Keisuke Takada, Minoru Noda
Rok vydání:	2015
Předmět:	Liposome Materials science Polydimethylsiloxane Nanotechnology Evaporation (deposition) chemistry.chemical_compound Surface micromachining chemistry Monolayer Electrical and Electronic Engineering Composite material Thin film Instrumentation Sheet resistance Strain gauge
Zdroj:	IEEE Sensors Journal. 15:7135-7141
ISSN:	2379-9153 1530-437X
DOI:	10.1109/jsen.2015.2470108
Popis:	A micro-cantilever with thermally stable strain gauge of a NiCr thin film and a self-assembled monolayer was fabricated by surface micromachining. Liposomes, as biosensing molecules, were immobilized on its surface. To prevent evaporation of the water solvent, a reservoir made of polydimethylsiloxane around the micro-cantilever was fabricated and covered with a glass plate. The resistance of the strain gauge increases with time in the amyloid beta ( $\text{A}\beta $ ) solution, because the cantilever is bent downward caused by interaction between $\text{A}\beta $ and liposomes immobilized on the micro-cantilever surface. Moreover, resistance change depends on the interaction ability of $\text{A}\beta $ proteins with liposomes. It is therefore indicated that the fabricated static mode micro-cantilever sensor with immobilized liposomes can be used to detect $\text{A}\beta $ proteins.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::965a07ca4960b001adce3f6b77ad81bf https://doi.org/10.1109/jsen.2015.2470108 Zobrazit plný text záznamu