Abstract TMP100: Hypoechogenicity, Ulceration and Presence of Debris in Carotid Plaques Are Associated With Higher Prevalence of Silent Brain Ischemic Lesions (SBIL) in Patients With Carotid Atheromatosis

Autor:	Ariel Luzzi, Natalia Balian, Clarisa Cea, Pedro Colla Machado, Maria C Zurru
Rok vydání:	2019
Předmět:	Advanced and Specialized Nursing Atheromatosis Pathology medicine.medical_specialty business.industry medicine.medical_treatment Medicine In patient Neurology (clinical) Embolization Cardiology and Cardiovascular Medicine business
Zdroj:	Stroke. 50
ISSN:	1524-4628 0039-2499
DOI:	10.1161/str.50.suppl_1.tmp100
Popis:	Introduction: Hypoechogenicity, ulceration and presence of debris in carotid plaques are associated with higher risk of embolization. When compared to echodense plaques, echolucid plaques are associated with a higher risk of ischemic stroke (IS) (3% vs 0.8%). However, the definition of symptomatic carotid plaque only takes clinical manifestations in account, disregarding the presence and accumulation of SBIL. Objective: To assess the prevalence of non-lacunar SBIL ipsilateral to a carotid stenosis superior to 50%, and establish a correlation with carotid doppler ultrasonography. Methods: Patients that had a carotid stenosis ≥50%, a brain MRI and a carotid doppler ultrasonography, and were evaluated at the Hospital Italiano of Buenos Aires between 01/01/2010 and 01/01/2018 were included. Every patient was under medical treatment. Results: Six hundred and forty six patients were included, 25% of which had bilateral carotid plaques, so 807 carotid plaques were analyzed. SBIL were found in 119 patients, being the most frequent: multiple patchy lesions (4%), single cortical lesions (3%), watershed territory lesions (3%), single subcortical lesions (2%) and cortico-subcortical lesions (1%). When comparing patients with SBIL against those without them (table 1), echolucid plaques were more frequent (73% vs. 14%, p=0.001), plaque-associated debris was more prevalent (43% vs 2%, p=0.001) and so were ulcerated plaques (36% vs 3%, p=0.001). Conclusions: These findings suggest patients with carotid atheromatosis with any of such aforementioned features present an elevated risk for developing SBIL. Although none of these patients suffered an IS, development of such SBIL might facilitate the future onset of cognitive and functional decline.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::9650b26bb04e8553e7906375a8dc5a04 https://doi.org/10.1161/str.50.suppl_1.tmp100 Zobrazit plný text záznamu