Chronic Dietary Intake of Plant-Derived Anthocyanins Protects the Rat Heart against Ischemia-Reperfusion Injury3
| Autor: | Andrea Matros, Michel de Lorgeril, Chiara Tonelli, Francxois Boucher, Norbert Nagy, Joël de Leiris, Cathie Martin, Patricia Salen, Domenico Rotilio, Lucia Giordano, Roberto Pilu, Hans-Peter Mock, Marie Claire Toufektsian, Silke Peterek, Maria Benedetta Donati, Katia Petroni |
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| Rok vydání: | 2008 |
| Předmět: |
Antioxidant
030309 nutrition & dietetics medicine.medical_treatment Ischemia Medicine (miscellaneous) Pharmacology Intestinal absorption 03 medical and health sciences chemistry.chemical_compound medicine Myocardial infarction 030304 developmental biology 2. Zero hunger Cardioprotection 0303 health sciences Nutrition and Dietetics business.industry fungi food and beverages medicine.disease 3. Good health carbohydrates (lipids) Biochemistry chemistry Coronary occlusion Anthocyanin business Reperfusion injury |
| Zdroj: | The Journal of Nutrition. 138:747-752 |
| ISSN: | 0022-3166 |
| DOI: | 10.1093/jn/138.4.747 |
| Popis: | Consumption of flavonoid-rich foods and beverages is thought to reduce the risk of cardiovascular diseases. Whereas the biological activities of flavonoids have been characterized in vitro, there are no clear experimental data demonstrating that chronic dietary intake and intestinal absorption of flavonoids actually protects the heart against ischemia-reperfusion injury. We tested whether long-term consumption of specific flavonoids (anthocyanins) included in normal food could render the heart of rats more resistant to myocardial infarction. Maize kernels that differed specifically in their accumulation of anthocyanins were used to prepare rodent food in which anthocyanins were either present or absent. Male Wistar rats were fed the anthocyanin-rich (ACN-rich) or the anthocyanin-free (ACN-free) diet for a period of 8 wk. Anthocyanins were significantly absorbed and detected in the blood and urine of only rats fed the ACN-rich diet. In Langendorff preparations, the hearts of rats fed the ACN-rich diet were more resistant to regional ischemia and reperfusion insult. Moreover, on an in vivo model of coronary occlusion and reperfusion, infarct size was reduced in rats that ate the ACN-rich diet than in those that consumed the ACN-free diet (P < 0.01). Cardioprotection was associated with increased myocardial glutathione levels, suggesting that dietary anthocyanins might modulate cardiac antioxidant defenses. Our findings suggest important potential health benefits of foods rich in anthocyanins and emphasize the need to develop anthocyanin-rich functional foods with protective activities for promoting human health. |
| Databáze: | OpenAIRE |
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