Hypoglycorrhachia in meningeal carcinomatosis

Autor:	Vincent T. de Vita, George P. Canellos
Rok vydání:	1966
Předmět:	Cancer Research Pathology medicine.medical_specialty business.industry Melanoma Blood-cerebrospinal fluid barrier Cancer Neurologic Signs medicine.disease Malignant disease Meningeal carcinomatosis Oncology Anaerobic glycolysis Hypoglycorrhachia Medicine business
Zdroj:	Cancer. 19:691-694
ISSN:	1097-0142 0008-543X
Popis:	A case of malignant melanoma with diffuse meningeal carcinomatosis and hypoglycorrhachia is presented. The combination of low spinal fluid glucose and bizarre or unexplained neurologic signs should bring to mind meningeal carcinomatosis. In the presence of known malignant disease and fever hypoglycorrhachia should stimulate a diligent search of the spinal fluid for recognizable malignant cells. The proposed mechanism for development of hypoglycorrhachia in malignant disease is either accelerated anaerobic glycolysis by malignant cells or mechanical blockade of the blood cerebrospinal fluid barrier or a combination of both factors. The advent of techniques for meningeal perfusion with cancer chemotherapeutic agents further emphasizes the importance of pursuing the diagnosis of neoplastic meningeal implants.
Databáze:	OpenAIRE
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