ChemInform Abstract: o-Nitroaniline Derivatives. Part 11. 4- and 7-Amino-1H-benzimidazole 3-Oxides

Autor:	David M. Smith, Ian W. Harvey, M. D. Mcfarlane, David J. Moody
Rok vydání:	1988
Předmět:	chemistry.chemical_classification Benzimidazole chemistry.chemical_compound chemistry Nitro compound General Medicine Medicinal chemistry O-nitroaniline
Zdroj:	ChemInform. 19
ISSN:	0931-7597
DOI:	10.1002/chin.198843194
Popis:	Of the two title compounds, the 4-amino isomer (1a) is easily obtained, either by reduction of the corresponding nitro compound, or in a five-step sequence from 2-nitro-1,3-phenylenediamine. The 7-amino isomer (1d) cannot be obtained by strictly analogous routes but it may be prepared in four steps from 2′,3′-dinitroacetanilide. Attempts to cyanomethylate monoacylated 3-nitro-1,2-phenylenediamines (8) lead to 1-acyl-2,3-dihydro-4-nitrobenzimidazoles (10).
Databáze:	OpenAIRE
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