Genetic variations in interleukin 6 rs1800795 polymorphism and the association with susceptibility to Hashimoto's thyroiditis
| Autor: | Sencer Ganidagli, Mustafa Kulaksizoglu, Mehmet Erdogan, Afig Berdeli |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
medicine.medical_specialty
biology business.industry 030209 endocrinology & metabolism Promoter Disease medicine.disease Thyroiditis 03 medical and health sciences 0302 clinical medicine Endocrinology 030220 oncology & carcinogenesis Internal medicine Genetic variation Genotype Immunology Genetics medicine biology.protein Etiology Gene polymorphism Interleukin 6 business Genetics (clinical) |
| Zdroj: | Meta Gene. 12:1-3 |
| ISSN: | 2214-5400 |
| DOI: | 10.1016/j.mgene.2016.12.010 |
| Popis: | Hashimoto's disease is a polygenic disorder with complex etiopathogenesis. The imbalance between pro- and anti-inflammatory cytokines may play a role in the etiology. We aimed to evaluate the relation between 174 promoter region of the interleukin 6 rs1800795 gene polymorphism in patients with Hashimoto's thyroiditis (HT). We studied 110 HT patients and 110 healthy controls. The evaluation of genotype for interleukin 6 rs1800795 gene polymorphism were performed by using PCR-RFLP method. The genotype of IL6 distribution did differ between the control group (CC 17.3%, GC 78.2%, GG 4.5%) and the HT patients (CC 29.1%, GC 46.4%, GG 24.5%) (p 0.05). Our results indicate that interleukin 6 rs1800795 polymorphism may be associated with susceptibility to HT in Turkish Patients. It is necessary to confirm the results and determine the underlying pathogenic mechanisms in further studies. |
| Databáze: | OpenAIRE |
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