Neurophysiological Characteristics of Patients with Juvenile Schizophrenia at the Late Follow-Up Stage
| Autor: | Kaleda Vg, I. V. Klochkova, S. A. Golubev, Irina Lebedeva |
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| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty business.industry General Neuroscience Disease Audiology medicine.disease Correlation 03 medical and health sciences Personality changes 030104 developmental biology 0302 clinical medicine Rhythm Schizophrenia Medicine Stage (cooking) business Oddball paradigm 030217 neurology & neurosurgery Psychopathology |
| Zdroj: | Neuroscience and Behavioral Physiology. 50:1140-1145 |
| ISSN: | 1573-899X 0097-0549 |
| DOI: | 10.1007/s11055-020-01016-8 |
| Popis: | Objective. To determine the neurophysiological features of schizophrenia at late (more than 20 years) follow- up and identify correlations between neurophysiological indicators and the clinical characteristics of the disease. Materials and methods. Patients of three groups were studied: those with a predominance of personality changes (group 1, 17 patients), those with negative disorders (group 2, 23 patients), and those with marked positive and negative disorders (group 3, 40 patients). The main study methods were psychopathological and neurophysiological, with assessment of event-linked potentials. Results and conclusions. A statistically significantly greater θ-rhythm frequency and a significantly lower α-rhythm frequency were found in group 3, the dominant frequency of the θ rhythm showing a correlation (positive) with the total score for positive disorders on the PANSS. No statistically significant between-group differences were seen in measures of the P300 wave of auditory event-related potential recorded in the oddball paradigm. These results are considered in the framework of views of the role of θ activity as a marker for hippocampal-prefrontal interactions. |
| Databáze: | OpenAIRE |
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