Mitigating effect of fermented Korean red ginseng extract with yeast and probiotics in 1-chloro-2,4-dinitrobenzene-induced skin allergic inflammation
| Autor: | Jeong-Eun Kwon, Eun-Hwa Sohn, Jung Dae Lim, Seon-A Jang, Hyejung Hong, Kyung-Ho Kim, Seung Namkoong, Mediana Hadiwidjaja, Se Chan Kang, Sung Ryul Lee, Manorma Negi, Hyun Jung Koo |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Health Toxicology and Mutagenesis p38 mitogen-activated protein kinases Pharmacology Toxicology Immunoglobulin E Pathology and Forensic Medicine Allergic inflammation 03 medical and health sciences Ginseng chemistry.chemical_compound 0302 clinical medicine medicine General Pharmacology Toxicology and Pharmaceutics Interleukin 4 Dexamethasone biology business.industry Public Health Environmental and Occupational Health Atopic dermatitis medicine.disease 030104 developmental biology chemistry Ginsenoside 030220 oncology & carcinogenesis biology.protein business medicine.drug |
| Zdroj: | Molecular & Cellular Toxicology. 15:111-121 |
| ISSN: | 2092-8467 1738-642X |
| Popis: | Atopic dermatitis (AD) frequently affects both infants and adults, impacting on the quality of life of the individual and imposing a significant psychosocial burden. The efficacy against AD-like skin lesions of the fermented form of Korea red ginseng (FRG), that contains ginsenoside metabolites, has not been investigated. FRG was prepared after fermentation of Korean red ginseng (KRG) extract in the presence of yeast and probiotics. The effects of FRG on skin allergic inflammation were then investigated by examining the frequency of scratching, and assessing the levels of representative allergic markers in 1-chloro-2,4-dinitrobenzene (DNCB)-challenged Balb/c mice. After two weeks of DNCB challenge, vehicle, dexamethasone (positive control), and FRG (10 and 50 μg/mL) were applied topically on skin lesions for 2 weeks. At the end of the experiment, scratching behavior, immunoglobulin E (IgE), and interleukin 4 (IL-4) levels were measured. The status of mitogen-activated protein kinases (MAPKs) and nuclear factor kappa B (NF-κB) were determined by immunoblot analysis in DNCB-treated primary splenocytes. Topical administration of FRG significantly suppressed scratching behavior, serum IgE, and IL-4 levels (P |
| Databáze: | OpenAIRE |
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