Comparative Evaluation of Serum C-Reactive Protein (CRP) Levels in the Different Histological Subtypes of Esophageal Cancer (Squamous Cell Carcinoma and Adenocarcinoma of Esophagus)
| Autor: | Maciej Szmitkowski, Maria Siewko, Barbara Mroczko, Jacek Niklinski, Jerzy Laudanski, Marta Łukaszewicz-Zając, Miroslaw Kozlowski |
|---|---|
| Rok vydání: | 2012 |
| Předmět: |
Microbiology (medical)
medicine.medical_specialty Pathology Clinical Biochemistry Gastroenterology Carcinoembryonic antigen Internal medicine medicine Immunology and Allergy Esophagus neoplasms Lymph node Survival analysis Univariate analysis biology business.industry Biochemistry (medical) C-reactive protein Public Health Environmental and Occupational Health Hematology Esophageal cancer medicine.disease digestive system diseases Medical Laboratory Technology medicine.anatomical_structure biology.protein Adenocarcinoma business |
| Zdroj: | Journal of Clinical Laboratory Analysis. 26:73-81 |
| ISSN: | 0887-8013 |
| DOI: | 10.1002/jcla.21486 |
| Popis: | Elevated C-reactive protein (CRP) levels have been found in patients with several malignancies. The aim of the present study was to analyze the diagnostic and prognostic values of CRP levels measurement in esophageal cancer (EC) patients in relation to its different histological subtypes (squamous cell carcinoma-ESCC and adenocarcinoma-AC of esophagus) and compared them with classic tumor markers-carcinoembryonic antigen (CEA) and squamous cell cancer antigen (SCC-Ag). The diagnostic sensitivity, specificity, and the areas under receiver operating characteristic curves (AUC) for all the proteins tested were defined. Serum CRP levels were statistically higher in EC, ESCC, and AC patients compared to healthy subjects and significantly increased in EC and ESCC patients with the presence of lymph node and distant metastases. The percentage of elevated CRP results in all the analyzed subgroups (EC, ESCC, and AC) was higher than CEA and SCC-Ag, similarly as AUC for CRP in comparison to SCC-Ag. Serum CRP level was a significant predictor of EC and ESCC patients' survival in univariate analysis. In conclusion, these results indicate that CRP can be used as an adjunct in evaluating the tumor markers-CEA and SCC-Ag and may improve the clinical diagnosis and follow-up of EC patients, especially for ESCC subgroup. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|