The role of thrombopoietin in post-operative thrombocytosis
| Autor: | Albert E. G. Kr. von dem Borne, Raymond J. W. M. Vet, Masja de Haas, Bart Kuenen B, Shreyas M. De Jong, Claudia C. Folman, Marike Ooms |
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| Rok vydání: | 2001 |
| Předmět: |
endocrine system
medicine.medical_specialty biology Thrombocytosis business.industry medicine.medical_treatment Liver cell food and beverages hemic and immune systems Hematology medicine.disease Proinflammatory cytokine fluids and secretions Endocrinology Cytokine Internal medicine embryonic structures Immunology biology.protein Medicine Platelet Thrombopoiesis business Interleukin 6 Thrombopoietin |
| Zdroj: | British Journal of Haematology. 114:126-133 |
| ISSN: | 0007-1048 |
| DOI: | 10.1046/j.1365-2141.2001.02888.x |
| Popis: | Thrombopoietin (Tpo), the main regulator of thrombocytopoiesis, is a probable candidate to play a role in the increase in platelet counts that is frequently seen after surgery. In the current study, serial blood samples of patients that underwent major surgery were analysed with respect to Tpo kinetics, platelet turnover and inflammatory cytokines. Platelet Tpo content and plasma Tpo levels rose before platelet counts increased, suggesting that Tpo was indeed responsible for the elevation in platelet counts. In addition, an increase in interleukin 6 (IL-6) levels, but not in IL-11 and tumour necrosis factor alpha levels, was seen before the rise in Tpo concentration. In vitro, IL-6 was shown to enhance Tpo production by the HepG2 liver cell line. Thus, increased Tpo levels after surgery, possibly resulting from enhanced Tpo production under the influence of IL-6 or other inflammatory cytokines, are involved in an enhanced thrombocytopoiesis. |
| Databáze: | OpenAIRE |
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