| Autor: |
Dan-Ping Huang, Yi-Jun Chen, Jie-Si Luo, Shao-Qian Chen, Jing Cheng, Yu Li, Cong Liang, Li-Na Wang, Zhong Fan, Xiao-Li Zhang, Xue-Qun Luo, Li-Bin Huang, Yan-Lai Tang |
| Rok vydání: |
2021 |
| Předmět: |
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| Zdroj: |
Journal of Cancer Research Updates. 10:51-55 |
| ISSN: |
1929-2279 |
| DOI: |
10.30683/1929-2279.2021.10.07 |
| Popis: |
Acute promyelocytic leukemia (APL) is a special type of acute myeloid leukemia (AML), accounting for about 5% to 10% of children with AML. At the genetic level, APL is featured by a unique chromosome translocation t(15;17) which results in the PML-RARA gene fusion. Most patients can be diagnosed by traditional karyotype analysis, Fluorescence-In-Situ Hybridization (FISH), or Reverse Transcription-Polymerase Chain Reaction (RT-PCR). We report the case of a child with acute promyelocytic leukemia (APL) who had characteristic chromosome translocation t(15;17) and rare PML-RARA gene mutation. This patient had an excellent response to chemotherapy, suggesting that this mutation will not affect the treatment and prognosis of APL. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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