An electrochemical sensor based on SiO2@TiO2-embedded molecularly imprinted polymers for selective and sensitive determination of theophylline
| Autor: | Junyong Sun, Liu Yanming, Aixia Zhao, Zhikai Wang, Pan Liu, Tian Gan |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Detection limit
Materials science 010401 analytical chemistry Analytical chemistry Molecularly imprinted polymer 02 engineering and technology 021001 nanoscience & nanotechnology Condensed Matter Physics Electrochemistry 01 natural sciences 0104 chemical sciences Electrochemical gas sensor chemistry.chemical_compound Molecular recognition Chemical engineering Methacrylic acid chemistry Linear range Electrode General Materials Science Electrical and Electronic Engineering 0210 nano-technology |
| Zdroj: | Journal of Solid State Electrochemistry. 21:3683-3691 |
| ISSN: | 1433-0768 1432-8488 |
| DOI: | 10.1007/s10008-017-3713-1 |
| Popis: | The present work is focused on a typical core-shell-structured SiO2@TiO2-based imprinted polymer composite, employed as a molecular recognition and sensing interface in the construction of an innovative electrochemical sensor. Herein, the methacrylic acid and a bronchodilator drug, theophylline, were used as functional monomer and template, respectively. The SiO2@TiO2 served as a potential signal transducer to shuttle electrons between the binding sites and the electrode. Such modification induced an electrocatalytic effect and thereby greatly improved the electrode kinetics. The analytical features of the developed theophylline sensor have been accessed, and the results have indicated that an increase of differential pulse voltammetric current as compared to the corresponding traditional imprinted polymer modified electrode. Moreover, the sensor has showed high sensitivity, wider linear range (0.01–40 μM), lower detection limit (1.2 nM), and satisfactory long-term stability, which was validated with the complex matrices of tea, human blood serum, and urine, without any matrix effect and cross-reactivity. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full text from SpringerLink