12T061A and 12T061C, two new julichrome family compounds, as radical scavengers from Streptomyces sp
| Autor: | Hiromasa Kiyota, Toshikazu Komoda, Yoshitaka Koseki, Naoko Saeki |
|---|---|
| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
biology 010405 organic chemistry Stereochemistry Chemistry Tumor cells biology.organism_classification 01 natural sciences Applied Microbiology and Biotechnology Microbiology Streptomyces 0104 chemical sciences 03 medical and health sciences 030104 developmental biology Biochemistry Hepg2 cells Inhibitory concentration 50 Spectrum analysis IC50 |
| Zdroj: | The Journal of General and Applied Microbiology. 62:1-6 |
| ISSN: | 1349-8037 0022-1260 |
| DOI: | 10.2323/jgam.62.1 |
| Popis: | We identified two new radical scavengers, 12T061A (1, C19H20O7) and 12T061C (2, C20H22O7), from a culture of the Streptomyces sp. Spectroscopic analysis indicated that these compounds are new julichrome family compounds. Compounds 1 and 2 showed radical-scavenging activity with an ED50 of 370 μM and 18 μM, respectively. Moreover, 1 showed tumor cell growth suppressive activity in HepG2 cells, (IC50: 3.6 μM); however, no suppressive activity was shown in 2 (IC50: > 100 μM). |
| Databáze: | OpenAIRE |
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