Mass spectrometric differentiation of the isomers of mono-methoxyethylamphetamines and mono-methoxydimethylamphetamines by GC–EI–MS–MS

Autor: Koichi Suzuki, Yuki Sakamoto, Shuntaro Matsuta, Kento Tsuboi, Takako Sato, Hiroshi Nishioka, Haruhiko Miyagawa, Kei Zaitsu, Michiaki Tatsuno, Hitoshi Tsuchihashi, Akira Ishii, Munehiro Katagi
Rok vydání: 2013
Předmět:
Zdroj: Forensic Toxicology. 31:292-300
ISSN: 1860-8973
1860-8965
DOI: 10.1007/s11419-013-0193-6
Popis: Mass spectrometric differentiation of the six isomers of mono-methoxyethylamphetamines (MeO-EAs) and mono-methoxydimethylamphetamines (MeO-DMAs) by gas chromatography–electron ionization–tandem mass spectrometry (GC–EI–MS–MS) was investigated. Based on their EI-mass spectra, the fragment ions at m/z 121 and 72 were selected as precursor ions for their regioisomeric and structurally isomeric differentiation, respectively. Collision-induced dissociation provides intensity differences in product ions among the isomers, enabling mass spectrometric differentiation of the isomers. Furthermore, high reproducibility of the product ion spectra at the optimized collision energy was confirmed, demonstrating the reliability of the method. To our knowledge, this is the first report on mass spectrometric differentiation of the six isomers of MeO-EAs and MeO-DMAs by GC–EI–MS–MS. Isomeric differentiation by GC–EI–MS–MS has a high potential to discriminate isomers of newly encountered designer drugs, making GC–MS–MS a powerful tool in the forensic toxicology field.
Databáze: OpenAIRE
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