ADAMTS-1: A new human ovulatory gene and a cumulus marker for fertilization capacity
| Autor: | Yuval Yung, Sarah Konopnicki, Ariel Hourvitz, Ettie Maman, J. Dor, Masha Brengauz |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
endocrine system
medicine.medical_specialty urogenital system media_common.quotation_subject Obstetrics and Gynecology Biology Oocyte Human chorionic gonadotropin In vitro maturation Human fertilization Endocrinology medicine.anatomical_structure Reproductive Medicine Internal medicine Follicular phase medicine Folliculogenesis Luteinizing hormone Ovulation hormones hormone substitutes and hormone antagonists media_common |
| Zdroj: | Fertility and Sterility. 94:S88 |
| ISSN: | 0015-0282 |
| DOI: | 10.1016/j.fertnstert.2010.07.339 |
| Popis: | ADAM-metallopeptidase with thrombospondin type 1 motifs-1 (ADAMTS-1) null female mice showimpaired follicular development and ovulatory processes. However, ADAMTS-1 expression and func-tion in human normal ovulation and folliculogenesis have not yet been determined. The objective of thisstudy is to study the expression patterns of ADAMTS-1 in human granulosa cells (GCs) obtained fromfollicles aspirated during in vitro maturation (IVM) and in vitro fertilization (IVF) procedures. We foundthat ADAMTS-1 expression is a luteinizing hormone/human chorionic gonadotropin (LH/hCG)-inducedgene whose expression in the mural GCs directly correlated with antral follicular growth. Interestingly,we were able to show a significant correlation between ADAMTS-1 expression in cumulus cells and thefertilization capacity of the related oocyte. In conclusion, human ADAMTS-1 is an ovulatory gene and itsexpression is LH/hCG- and follicle-size dependent. The correlation between its expression in cumulusGCs and oocyte fertilization capacity suggests a role for ADAMTS-1 in human cumulus function.© 2010 Elsevier Ireland Ltd. All rights reserved. |
| Databáze: | OpenAIRE |
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