Co-expression of NaVβ subunits alters the kinetics of inhibition of voltage-gated sodium channels by pore-blocking μ-conotoxins

Autor:	Doju Yoshikami, Baldomero M. Olivera, Jean Rivier, Joanna Gajewiak, Grzegorz Bulaj, Layla Azam, Michael J. Wilson, Min Min Zhang
Rok vydání:	2013
Předmět:	Pharmacology Gene isoform Saxitoxin chemistry.chemical_classification Sodium channel Peptide Biology chemistry.chemical_compound Sodium channel blocker Biochemistry chemistry NAV1 Biophysics Tetrodotoxin Conotoxin
Zdroj:	British Journal of Pharmacology. 168:1597-1610
ISSN:	0007-1188
DOI:	10.1111/bph.12051
Popis:	Background and Purpose Voltage-gated sodium channels (VGSCs) are assembled from two classes of subunits, a pore-bearing α-subunit (NaV1) and one or two accessory β-subunits (NaVβs). Neurons in mammals can express one or more of seven isoforms of NaV1 and one or more of four isoforms of NaVβ. The peptide μ-conotoxins, like the guanidinium alkaloids tetrodotoxin (TTX) and saxitoxin (STX), inhibit VGSCs by blocking the pore in NaV1. Hitherto, the effects of NaVβ-subunit co-expression on the activity of these toxins have not been comprehensively assessed.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::95dcb57c3b37ec5b3fb96785c7225000 https://doi.org/10.1111/bph.12051 Zobrazit plný text záznamu Plný text ve formátu PDF Plný text ve formátu HTML
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