Iodine binding and release from antimicrobial hemostatic polymer foams
| Autor: | Christopher L. McGann, Jeffrey G. Lundin, James H. Wynne, Nickolaus K. Weise, Robert B. Balow, Luis A. Estrella, Benjamin C. Streifel |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
chemistry.chemical_classification
Polymers and Plastics General Chemical Engineering Kinetics chemistry.chemical_element 02 engineering and technology General Chemistry Polymer 010402 general chemistry 021001 nanoscience & nanotechnology Antimicrobial Iodine 01 natural sciences Biochemistry 0104 chemical sciences Matrix (chemical analysis) chemistry.chemical_compound chemistry Emulsion Materials Chemistry Environmental Chemistry Triiodide 0210 nano-technology High iodine Nuclear chemistry |
| Zdroj: | Reactive and Functional Polymers. 135:44-51 |
| ISSN: | 1381-5148 |
| DOI: | 10.1016/j.reactfunctpolym.2018.12.009 |
| Popis: | Hemostatic macroporous polymer foams synthesized via high internal phase emulsion (HIPE) templating were loaded with iodine to impart broad-spectrum antimicrobial activity. The effects of kaolin loading and iodine content on structure and antimicrobial activity were identified. ATR-FTIR, Raman, and XRD provided detailed insight into the complexation of iodine with the cross-linked PEG-NaAA-PEG macroporous polymer matrix. Iodine was found to incorporate into the foams exclusively as triiodide (I3−) ion coordinated to the various carbonyls throughout the polymer structure. Continued, sustained release kinetics of iodine over 48 h was achieved at high iodine loading, while low iodine yielded burst release kinetics. Broad spectrum antimicrobial activity dependent on iodine loading was demonstrated with significant zone of inhibition against E. coli, K. pneumoniae, P. aeruginosa, and S. aureus. This represents the first report of detailed complexation and sustained release of antimicrobial iodine into highly absorbent, hemostatic, and biocompatible polymeric wound dressing material with potential to combat bacterial resistance in infected wounds. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect