Development of a Green and Sustainable Manufacturing Process for Gefapixant Citrate (MK-7264) Part 1: Introduction and Process Overview

Autor: Michael J. Di Maso, Embarek Alwedi, Guy R. Humphrey, Richard Desmond, Louis-Charles Campeau, Lisa Jellett, John R. Naber, Hong Ren, Hsieh Yao D. Chang, Douglas A. L. Otte, Hong Gao, Michael A. Zompa, Si-Wei Zhang, Gary E. Martin, Alfred Y. Lee, Wenjun Liu, Francisco J. Guzman, Kevin M. Maloney, Feng Peng, Elizabeth Fisher, Rebecca T. Ruck, Dan Lehnherr, Anne E. Mohan, Glenn Spencer, Siqing Song, Kallol Basu, Rebecca A. Arvary, Sachin Lohani
Rok vydání: 2020
Předmět:
Zdroj: Organic Process Research & Development. 24:2445-2452
ISSN: 1520-586X
1083-6160
DOI: 10.1021/acs.oprd.0c00248
Popis: A robust, green, and sustainable manufacturing process has been developed for the synthesis of gefapixant citrate, a P2X3 receptor antagonist that is under investigation for the treatment of refrac...
Databáze: OpenAIRE