Role of Sentinel Lymph Node Biopsy in Microinvasive Breast Cancer
Autor: | Amulya Alapati, Joanne Szewczyk, Alessandra Mele, Ted A. James, Jaime A. Pardo, Stephanie K. Serres, Betty Fan |
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Rok vydání: | 2020 |
Předmět: |
medicine.medical_specialty
business.industry Sentinel lymph node Cancer Sentinel node Ductal carcinoma medicine.disease Metastasis 03 medical and health sciences Axilla 0302 clinical medicine Breast cancer medicine.anatomical_structure Oncology 030220 oncology & carcinogenesis medicine Carcinoma 030211 gastroenterology & hepatology Surgery Radiology business |
Zdroj: | Annals of Surgical Oncology. 27:4468-4473 |
ISSN: | 1534-4681 1068-9265 |
Popis: | Microinvasive ductal carcinoma (DCISM), defined as DCIS with a focus of invasive carcinoma ≤ 1 mm, can be managed similarly to pure DCIS; however, management of the axilla in DCISM has been a subject of debate. Reports in the literature differ on the utility and necessity of sentinel lymph node biopsy (SLNB) for DCISM. The aim of the present study was to identify risk factors for nodal disease in patients with DCISM, which can help develop a selective approach to SLNB in this patient population. The National Cancer Database was used to select patients with DCISM (pT1mi), diagnosed from 2012 to 2015, who underwent SLNB. Multivariable regression analysis was performed to determine associations between sentinel lymph node metastasis and relevant clinical variables. Our cohort comprised of 2609 patients with pT1mi who underwent SLNB. Of these, 76 (2.9%) were found to have sentinel lymph node metastases on final pathology. Low/intermediate grade tumors were associated with decreased SLN metastasis (OR 0.50, CI 0.28–0.92). Age and receptor status of the tumor did not have a clear association in predicting SLN metastases. The rate of sentinel node metastases in DCISM is low at only 2.9% in this national study. Tumor grade was identified as influencing the risk of SLN metastases. This information can factor into shared decision-making for SLNB in patients with DCISM. |
Databáze: | OpenAIRE |
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