Hmgcr promotes a long-range signal to attract Drosophila germ cells independently of Hedgehog
| Autor: | Kim Kenwrick, Andrew D. Renault, Amrita Mukherjee |
|---|---|
| Rok vydání: | 2019 |
| Předmět: |
0303 health sciences
Cell type Cell Cell Biology Biology Signal Cell biology 03 medical and health sciences Paracrine signalling 0302 clinical medicine medicine.anatomical_structure medicine lipids (amino acids peptides and proteins) Germ Gene Hedgehog 030217 neurology & neurosurgery Germ cell 030304 developmental biology |
| Zdroj: | Journal of Cell Science. 132 |
| ISSN: | 1477-9137 0021-9533 |
| Popis: | During development, many cell types migrate along stereotyped routes determined through deployment of cell surface or secreted guidance molecules. Although we know the identity of many of these molecules, the distances over which they natively operate can be difficult to determine. Here, we have quantified the range of an attractive signal for the migration of Drosophila germ cells. Their migration is guided by an attractive signal generated by the expression of genes in the 3-hydroxy-3-methyl-glutaryl-coenzyme A reductase (Hmgcr) pathway, and by a repulsive signal generated by the expression of Wunens. We demonstrate that the attractive signal downstream of Hmgcr is cell-contact independent and acts at long range, the extent of which depends on Hmgcr levels. This range would be sufficient to reach all of the germ cells for their entire migration. Furthermore, Hmgcr-mediated attraction does not require Wunens but can operate simultaneously with Wunen-mediated repulsion. Finally, several papers posit Hedgehog (Hh) as being the germ cell attractant downstream of Hmgcr. Here, we provide evidence that this is not the case. |
| Databáze: | OpenAIRE |
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