Two new sesterterpenoids, terretonins H and I, from the marine-derived fungus Aspergillus ustus
| Autor: | Alexandra S. Kuzmich, Vladimir A. Denisenko, N. I. Menzorova, Shamil Sh. Afiyatullov, Dmitrii V. Berdyshev, Natalia N. Kirichuk, Ekaterina A. Yurchenko, Olesya I Zhuravleva, G. K. Oleinikova, M. A. Pushilin |
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| Rok vydání: | 2016 |
| Předmět: |
010405 organic chemistry
Embryo Plant Science Fungus Biology biology.organism_classification 01 natural sciences Biochemistry Sperm Strongylocentrotus intermedius 0104 chemical sciences Microbiology 010404 medicinal & biomolecular chemistry Aspergillus ustus biology.animal embryonic structures Cerebroside D Agronomy and Crop Science Sea urchin Human cancer Biotechnology |
| Zdroj: | Phytochemistry Letters. 17:135-139 |
| ISSN: | 1874-3900 |
| Popis: | Two new sesterterpenoids, terretonins H ( 1 ) and I ( 2 ), together with two known compounds, strobilactone A ( 3 ) and cerebroside D ( 4 ), were isolated from the lipophilic extract of the marine-derived fungus Aspergillus ustus KMM 4664. The structures of compounds 1 and 2 were determined based on spectroscopic methods and confirmed by X-ray crystallographic analysis of terretonin H. All compounds were tested for cytotoxic and embryotoxic effects using sperm and developing embryos of the sea urchin Strongylocentrotus intermedius and human cancer cells. |
| Databáze: | OpenAIRE |
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