INFLUENCE OF PEPTIDE IMITATING A-SPIRAL OF B ERYTHROPOETHIN ON THE DEVELOPMENT OF MORPHOFUNCTIONAL DISORDERS IN EXPERIMENTAL PRECLAMPPS

Autor:	Anastasia V. Gureeva, M.A. Zatolokina, A.V. Polyanskaya, E.S. Zatolokina, I.V. Golubev, E.V. Avdeyeva, V.V. Gureev
Rok vydání:	2020
Předmět:	chemistry.chemical_classification Chemistry embryonic structures Peptide reproductive and urinary physiology Spiral Cell biology
Zdroj:	Journal of Volgograd State Medical University. 17:53-56
ISSN:	1994-9499 1994-9480
DOI:	10.19163/1994-9480-2020-2(74)-53-56
Popis:	Preeclampsia remains a formidable disease in the second half of pregnancy. Therefore, the search for new drugs for the treatment and prevention of preeclampsia is an urgent task of modern pharmacology. Materials and methods. The experiment was performed on female Wistar rats. The studied drugs were administered from 10 to 21 days of pregnancy. Functional tests were performed on the 21st day of pregnancy. Results. The use of a peptide that imitates erythropoietin а-helix B in experimental preeclampsia leads to a pronounced correction of pathological changes: blood pressure decreased, microcirculation in the placenta increased, and the morphological picture in the placenta improved. Resume. The results indicate the promise of the use of a peptide imitating а-helix B erythropoietin in experimental preeclampsia.
Databáze:	OpenAIRE
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