Effects of Cyclooxygenase-2 Inhibitor on Equine Gastric Mucosa
| Rok vydání: | 2012 |
|---|---|
| Předmět: |
medicine.medical_specialty
business.industry medicine.medical_treatment Gastroenterology Washout period digestive system diseases chemistry.chemical_compound medicine.anatomical_structure chemistry Firocoxib Internal medicine medicine Gastric mucosa Phenylbutazone Margo plicatus business Saline Omeprazole After treatment medicine.drug |
| Zdroj: | Journal of the Japan Veterinary Medical Association. 65:597-600 |
| ISSN: | 2186-0211 0446-6454 |
| DOI: | 10.12935/jvma.65.597 |
| Popis: | SUMMARY This study was performed to evaluate the effects of Cyclooxygenaseh2 inhibitor on equine gastric mucosa. Six healthy thoroughbred horses each received saline (20 ml), phenylbutazone (4.4 mg/kg), firocoxib (5.0 mg/kg), and a combination of omeprazole and phenylbutazone (1.0 and 4.4 mg/kg, respectively) perorally once a day for 7 days with a 14-day washout period between treatments. Gastric mucosa was evaluated using gas- tric endoscopy before and seven days after treatment. In phenylbutazone treatment, an ulcer of 2.0 cm in diam- eter was observed in margo plicatus, and the ulcer score increased significantly at day 7. With the other treat- ments, the ulcer score did not change. These results indicate that the omeprazole has a preventive effect on gastric ulcer induced by phenylbutazone, and firocoxib has less effect on equine gastric mucosa than phenylbu |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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