| Popis: |
Stokesia laevis (common name Stokes aster) ethanolic extract (Slae26) containing 5 mg GAE/mL extract was investigated to establish cytotoxicity and anti-proliferative effects. The assays were performed on normal murine fibroblast cell line L929 and malignant murine melanoma cell line B16, respectively; for the first time in literature data, potential cytotoxic and anti-proliferative effects of the ethanolic extract from S. laevis on both, normal murine fibroblast cell line L929, and murine melanoma cell line B16 have been proved. The study is supplemented by molecular docking simulations of the major components of Slae26 against human tyrosinase receptor, to evaluate possible melanogenesis inhibition. |
