| Autor: | Volker Seibert, Chunshui Zhou, Edward Rhee, Kareem Abderazzaq, Dieter A. Wolf, Rebecca Lopez, Corinna Prohl, Ida Schoultz |
|---|---|
| Rok vydání: | 2002 |
| Předmět: |
0303 health sciences
biology Protein subunit 030302 biochemistry & molecular biology Biochemistry F-box protein Ubiquitin ligase Cell biology 03 medical and health sciences Ubiquitins Ubiquitin SKP Cullin F-Box Protein Ligases embryonic structures Skp1 biology.protein Molecular Biology Cullin 030304 developmental biology |
| Zdroj: | BMC Biochemistry. 3:22 |
| ISSN: | 1471-2091 |
| DOI: | 10.1186/1471-2091-3-22 |
| Popis: | Background SCF ubiquitin ligases share the core subunits cullin 1, SKP1, and HRT1/RBX1/ROC1, which associate with different F-box proteins. F-box proteins bind substrates following their phosphorylation upon stimulation of various signaling pathways. Ubiquitin-mediated destruction of the fission yeast cyclin-dependent kinase inhibitor Rum1p depends on two heterooligomerizing F-box proteins, Pop1p and Pop2p. Both proteins interact with the cullin Pcu1p when overexpressed, but it is unknown whether this reflects their co-assembly into bona fide SCF complexes. |
| Databáze: | OpenAIRE |
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