Synthesis and cytotoxicity of novel 6H-indolo[2,3-b]quinoxaline derivatives

Autor:	Srigiridhar Kotamraju, Sreenivas Avula, Satish Koppireddi, Anantha K Kanugula, Rambabu Yadla, Jayaram Reddy Komsani
Rok vydání:	2012
Předmět:	1 2 3-Triazole biology Stereochemistry Isatin Organic Chemistry biology.organism_classification HeLa chemistry.chemical_compound Quinoxaline chemistry Cell culture Click chemistry Cytotoxic T cell General Pharmacology Toxicology and Pharmaceutics Cytotoxicity
Zdroj:	Medicinal Chemistry Research. 22:3712-3718
ISSN:	1554-8120 1054-2523
DOI:	10.1007/s00044-012-0373-7
Popis:	A series of new 6-[(N 1-aryl-1H-1,2,3-triazol-4-yl)methyl]-6H-indolo[2,3-b]quinoxa-line derivatives 7a i–ix and 7b i–vi is synthesized by a simple multi-step protocol starting from isatin 1a or 5-fluoroisatin 1b. These compounds are screened against lung (A-549), cervical (HeLa), and prostate (DU-145) human cancer cell lines to evaluate their cytotoxic effect. Of all the compounds tested, five compounds showed moderate cytotoxicity against human reproductive organ cell lines, while others exhibited lower cytotoxicity against different human cancer cell lines. An elegant synthesis of these complex molecules and their cytotoxicity data are presented.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_________::9580ae63faefd0ac84becedbc72cacae https://doi.org/10.1007/s00044-012-0373-7 Zobrazit plný text záznamu Full text from SpringerLink