| Popis: |
Fatty acids are distributed by the bloodstream to peripheral tissues that utilize these molecules for energy production, for storage, or in biosynthetic pathways. Fatty acids are transported in plasma in the form of triacylglycerols in chylomicrons and very-low-density lipoproteins, or noncovalently bound to serum albumin. Lipoprotein lipase liberates the ester-bound fatty acids. On their way from the capillary to the intracellular organelles, fatty acids have to pass a series of aqueous spaces and membrane barriers (Figure 1). Fatty acids may be taken up from blood and transferred to the interstitial space by the endothelial cells of the capillary wall. Albumin-fatty acid complexes may also pass the endothelium through clefts or by way of plasmalemmal vesicles that pass through the capillary endothelial cell (Milici et al., 1987). |
