Patterns of recurrence of rectal cancer after potentially curative surgery

Autor: Alfred M. Cohen, James J. Galdibini, Gordon A. Donaldson, Leonard L. Gunderson, Tyvin A. Rich, Robert A. Lew
Rok vydání: 1983
Předmět:
Zdroj: Cancer. 52:1317-1329
ISSN: 1097-0142
0008-543X
DOI: 10.1002/1097-0142(19831001)52:7<1317::aid-cncr2820520731>3.0.co;2-6
Popis: The results of surgical treatment alone for 142 cases of carcinoma of the rectum and rectosigmoid from the Massachusetts General Hospital were reviewed. The incidence of local failure as any component of failure was found to be strongly dependent on the pathologic stage, and for Dukes' A was 8.0% (3/39); Dukes' B, 31% (18/59), and Dukes' C, 50% (22/44). The incidence of local failure for tumors without lymph node metastasis was 17% with only microscopic extension through the wall (modified Astler-Coller Stage MAC-B2m), but increased to 54% in tumors that were adherent to or invading adjacent organs and structures (MAC-B3). Similarly, in tumors with positive lymph nodes, there was a 36% incidence of local failure for tumors confined to the wall or with only microscopic extension through the wall (MAC-C1/C2m), compared to a 67% incidence for tumors with adherence or involvement of adjacent organs (MAC-C3). Other predictors of local recurrence were the tumor location, grade, number of lymph nodes, and blood vessel invasion. The pathologic factors predicting distant metastasis are also presented. Five-year survival for Dukes' A was 77% (30/39); Dukes' B, 44% (26/59); and Dukes' C, 23% (10/44). The implications for future adjuvant therapy based on the identification of patients with the highest risk for local and distant failure are discussed.
Databáze: OpenAIRE
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