Diffusion and Molecular Dynamics of Lipo-Fullerenes in Phospholipid Membranes Studied by NMR and Quasi-Elastic Neutron Scattering
| Autor: | Helene Casalta, Andreas Hirsch, Xavier Camps, Otto Vostrowsky, Thomas M. Bayerl, Michael Hetzer, Paul Karakatsanis |
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| Rok vydání: | 2000 |
| Předmět: |
chemistry.chemical_classification
Physics::Biological Physics Fullerene Bilayer Diffusion Neutron scattering Condensed Matter::Soft Condensed Matter Crystallography Molecular dynamics chemistry.chemical_compound chemistry Dipalmitoylphosphatidylcholine Physics::Atomic and Molecular Clusters Proton NMR Physical and Theoretical Chemistry Alkyl |
| Zdroj: | The Journal of Physical Chemistry A. 104:5437-5443 |
| ISSN: | 1520-5215 1089-5639 |
| DOI: | 10.1021/jp0000634 |
| Popis: | Lipo-fullerenes are lipophilic C60 derivatives (six pairs of alkyl chains symmetrically grafted to the C60 cage) that intercalate in phospholipid bilayers by the formation of rodlike structures of nanoscopic dimensions. Proton NMR measurements in the fringe field of a superconducting magnet (SFF-NMR) were employed to measure the long-range self-diffusion of lipo-fullerenes intercalated in oriented multilayers of dipalmitoylphosphatidylcholine (DPPC) between 27 and 70 °C. The lipo-fullerene diffusion was found to be an order of magnitude slower than that of the DPPC in the host bilayer. The lipo-fullerene diffusion continued largely unaffected even under conditions when the host bilayer assumed a solidlike gel state, indicating a decoupling of lipo-fullerene and DPPC motion. Quasi-elastic neutron scattering (QENS) was used to study the molecular dynamics of the lipo-fullerenes within the bilayer at four energy resolutions of the spectrometer (1, 19, 62, and 500 μeV), covering selectively the gighertz to te... |
| Databáze: | OpenAIRE |
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