A facile synthesis of benzo[b]thiophene derivatives

Autor: Mitsuaki Watanabe, Mutsuhiro Date, Kenji Kawanishi, Sunao Furukawa, Ryuji Akiyoshi
Rok vydání: 1991
Předmět:
Zdroj: Journal of Heterocyclic Chemistry. 28:173-176
ISSN: 1943-5193
0022-152X
DOI: 10.1002/jhet.5570280130
Popis: Lithiation of S-(2-methylphenyl) N, N, N', N'- tetramethylphosphorodiamidothioate with sec-BuLi at #75105° gave the corresponding benzylic anion which was acylated with various aromatic esters to give various deoxybenzoin derivatives in moderate to high yields. Acidic treatment of these products in refluxing formic acid gave 2-arylbenzo[b]thiophene derivatives. 2-Methylbenzo[b]thiophene and benzo[b]thiophen-2(3H)-one were also prepared using the similar procedure
Databáze: OpenAIRE
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