Recurrent Coronary Artery Vasospasm in a Patient with Hepatocellular Carcinoma Treated with Sorafenib: a Case Report and Literature Review

Autor:	Jai Hoon Yoon, Ho Soon Choi, Byung Chul Yoon, Hang Rak Lee, Dae Won Jun, Dae Hyun Lim, Kyung Soo Kim, Oh Young Lee
Rok vydání:	2020
Předmět:	Sorafenib Oncology medicine.medical_specialty Cardiotoxicity medicine.drug_class business.industry medicine.disease Tyrosine-kinase inhibitor Renal cell carcinoma Coronary vasospasm Internal medicine Hepatocellular carcinoma medicine Liver cancer business Tyrosine kinase medicine.drug
Zdroj:	Journal of Liver Cancer. 20:67-71
ISSN:	2383-5001 2288-8128
Popis:	Tyrosine kinase inhibitors are widely used as targeted treatments for various malignancies. Sorafenib is an orally active tyrosine kinase inhibitor that blocks the signaling pathways of several growth factors. Its use is approved for various malignancies such as unresectable hepatocellular carcinoma, renal cell carcinoma, and gastrointestinal stromal tumors. Several adverse effects have been reported in the literature; however, cardiotoxicity is rare. We present a case of recurrent coronary vasospasm caused by short-term administration (5 days) of sorafenib. Since it caused refractory ischemia after re-administration, we had no choice but to stop the treatment. (J Liver Cancer 2020;20:67-71)
Databáze:	OpenAIRE
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