Regulators of spindle microtubules and their mechanisms: Living together matters
| Autor: | R. Bhagya Lakshmi, Tapas Manna, Vishnu M. Nair |
|---|---|
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
biology Cell division Kinetochore Clinical Biochemistry Chromosome Cell Biology Biochemistry Cell biology Spindle apparatus Kinetochore microtubule 03 medical and health sciences 030104 developmental biology 0302 clinical medicine Tubulin Microtubule Genetics biology.protein Molecular Biology Mitosis 030217 neurology & neurosurgery |
| Zdroj: | IUBMB Life. 70:101-111 |
| ISSN: | 1521-6543 |
| DOI: | 10.1002/iub.1708 |
| Popis: | Development and survival of all eukaryotic organisms depend on equal partitioning of their chromosomes between the two newly formed daughter cells during mitosis. The mitotic spindle performs the task of physically segregating the chromosomes through multiple stages of mitosis. During this process, kinetochore-microtubule attachment requires to be selectively stabilized to hold the chromosomes, but at the same time, it has to be flexible enough to allow kinetochore microtubule dynamicity and chromosome movements. Research during the last decade or so has identified a number of proteins associated with the spindle microtubule plus ends that regulate these processes and orchestrate forces to spatially organize and separate the chromosomes. In this review, we describe the molecular details of those regulators and their mechanisms of action at the kinetochore-microtubule interface. © 2018 IUBMB Life, 70(2):101-111, 2018. |
| Databáze: | OpenAIRE |
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