Investigation of Catechol-O-methyltransferase (COMT) gene Val158Met polymorphism in ovarian cancer
| Autor: | Seda Gulec Yilmaz, Altay Burak Dalan, Turgay Isbir, Rukset Attar, Zerrin Barut, Fatma Tuba Akdeniz, İpek Yağmur Abaoğlu |
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| Rok vydání: | 2021 |
| Předmět: |
Genetics
Turkish population Catechol-O-methyl transferase business.industry Wild type Obstetrics and Gynecology Heterozygote advantage Genetic analysis Genotype frequency 03 medical and health sciences 0302 clinical medicine 030220 oncology & carcinogenesis Genotype Medicine 030212 general & internal medicine Allele business |
| Zdroj: | Journal of the Turkish-German Gynecological Association. 22:42-46 |
| ISSN: | 1309-0380 1309-0399 |
| DOI: | 10.4274/jtgga.galenos.2020.2020.0091 |
| Popis: | Objective Catechol-O-methyltransferase (COMT), the product of the COMT gene, detoxifies the carcinogenic catechol estrogens. The aim of the present study was to examine the relationship between COMT Val158Met polymorphism and the risk of ovarian cancer. Material and methods The study groups consist of 94 individuals as a patients group with ovarian cancer (n=47) and control group (n=47). The allele and genotype frequencies were determined according to Hardy-Weinberg equilibrium (HWE). The allele and genotype frequencies. determined according to HWE. Genetic analysis were performed by real-time-polymerase chain reaction instrument, and the statistical analysis were performed by SPSS program. Results Although no significant relationship was obtained among groups (p=0.413) regarding COMT gene Val158Met polymorphism, the genotype frequencies for COMT Val158Met (rs4860) polymorphism in groups was homozygote wild type GG genotype 25.5%, heterozygote GA genotype 46.8%, homozygote mutant AA genotype 27.7%. Conclusion This study is the first to investigate the relationship between ovarian cancer and the Val158Met polymorphism in the COMT gene in a Turkish population. No statistically significant relationship was identified among genotypes belonging to the patient and control groups although sample sizes were relatively small and the analysis should be repeated in a larger cohort. |
| Databáze: | OpenAIRE |
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