An investigation of quinolizidine alkaloids by the optical rotatory dispersion (ORD) method
| Autor: | M. A. Ramazanova, Kh. A. Aslanov, A. I. Ishbaev, A. S. Sadykov |
|---|---|
| Rok vydání: | 1972 |
| Předmět: |
chemistry.chemical_classification
Quinolizidine Double bond Chemistry Stereochemistry Sparteine Plant Science General Chemistry Ring (chemistry) General Biochemistry Genetics and Molecular Biology Lupinine chemistry.chemical_compound Lactam medicine Optical rotatory dispersion Cis–trans isomerism medicine.drug |
| Zdroj: | Chemistry of Natural Compounds. 8:322-326 |
| ISSN: | 1573-8388 0009-3130 |
| DOI: | 10.1007/bf00563740 |
| Popis: | 1. The ORD curves of alkaloids of the sparteine, lupinine, and cytisine groups and of some derivatives of aphyllinic acid have been investigated. In the compounds investigated with an α-pyridone ring the epimers with the trans-quinolizidine linkage of the nuclei have a greater molecular amplitude than the corresponding cis isomers. 2. It has been shown that the alkaloids with a lactam group in an outer ring have higher molecular amplitudes than the corresponding compounds with the >N—C=O group in an inner ring. A dependence of the shape, sign, and molecular amplitude of the curves on the type of linkage of the quinolizidine nuclei and also a dependence of the molecular rotation of the position of a double bond in ring A or D have been given. 3. Derivatives of lupinine and of aphyllinic acid are characterized by curves approximating to a smooth shape with low-intensity anomalies, and in the case of the derivatives of aphyllinic acid studied they are shifted in the long-wave direction. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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