Characteristics of 9194 Patients With Left Ventricular Hypertrophy
| Autor: | RB Devereux, Björn Dahlöf, Gareth Beevers, Markku S. Nieminen, Ole Lederballe-Pedersen, S E Kjeldsen, H Wedel, H Ibsen, Thomas Hedner, Frej Fyhrquist, Stevo Julius, Krister Kristianson, L. H. Lindholm, Per Omvik, U de Faire, Suzanne Oparil |
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| Rok vydání: | 1998 |
| Předmět: |
medicine.medical_specialty
education.field_of_study Framingham Risk Score business.industry Population Left ventricular hypertrophy medicine.disease Essential hypertension Angiotensin II Surgery Losartan Blood pressure Internal medicine Internal Medicine medicine Cardiology cardiovascular diseases Myocardial infarction education business medicine.drug |
| Zdroj: | Hypertension. 32:989-997 |
| ISSN: | 1524-4563 0194-911X |
| Popis: | Abstract —Losartan was the first available orally administered selective antagonist of the angiotensin II type 1 receptor developed for the treatment of hypertension. The Losartan Intervention For Endpoint (LIFE) Reduction in Hypertension Study is a double-blind, prospective, parallel group study designed to compare the effects of losartan with those of the β-blocker atenolol on the reduction of cardiovascular morbidity and mortality. Patients with essential hypertension, aged between 55 and 80 years, and ECG-documented left ventricular hypertrophy (LVH) were included. Altogether, 9223 patients in Scandinavia, the United Kingdom, and the United States were randomized from June 1995 through April 1997, and 9194 remain after exclusion of a study center at which irregularities were discovered. This population of hypertensives (mean systolic/diastolic blood pressure, 174.4/97.8 mm Hg) with LVH comprises women (54.1%) and men, mostly retired from active work (mean age, 66.9 years), with a high prevalence of overweight (mean body mass index, 28.0 kg/m 2 ), diabetes mellitus (12.3%), lipid disorders (18.0%), and symptoms or signs of coronary heart disease (15.1%). There were fewer current smokers ( |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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