Regional variation in the secretory function of visceral fat depots from severely obese women (688.4)
| Autor: | Denis R. Joanisse, Jean Bergeron, Simon Biron, Pascale Mauriège, Denis Richard, Isabelle Lemieux, Amélie Cartier, Picard Marceau |
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| Rok vydání: | 2014 |
| Předmět: |
0303 health sciences
medicine.medical_specialty Lipoprotein lipase biology Adiponectin business.industry Adipose tissue Lipid metabolism Biochemistry 03 medical and health sciences 0302 clinical medicine Endocrinology Adipogenesis Internal medicine Genetics medicine biology.protein Tumor necrosis factor alpha Lipase business Molecular Biology Plasminogen activator 030217 neurology & neurosurgery 030304 developmental biology Biotechnology |
| Zdroj: | The FASEB Journal. 28 |
| ISSN: | 1530-6860 0892-6638 |
| DOI: | 10.1096/fasebj.28.1_supplement.688.4 |
| Popis: | Because of its hepatic venous drainage, visceral fat accumulation is an important risk factor for obesity-related metabolic complications. Objective: To examine the secretory function of a properitoneal fat, the round ligament (RL) in severely obese women. Methods: Metabolic biomarkers, adipogenic, pro- vs. anti-inflammatory, and prothrombotic characteristics were assessed in the RL adipose tissue (AT), and compared to visceral depots, the omental (OME) and mesenteric (MES) fat, in forty-eight severely obese women (BMI, 54 ± 11 kg/m2), aged 38 ± 9 yrs. Expression of key enzymes involved in lipid metabolism (lipoprotein lipase, LPL; hormone-sensitive lipase, HSL and phosphodiesterase-3B, PDE-3B), and of adipogenic factors (peroxisome proliferator activated receptors-γ1/2, PPAR-γ1/2) was measured by real-time PCR. AT mRNA levels of plasminogen activator inhibitor-1 (PAI-1), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α) and adiponectin were also determined. Results: AT-LPL mRNA levels were the highes... |
| Databáze: | OpenAIRE |
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