Fast and simultaneous determination of nimesulide and paracetamol by batch injection analysis with amperometric detection on bare boron-doped diamond electrode
| Autor: | Eduardo M. Richter, Polyana Fernandes Pereira, Mariana C. Marra, Rodrigo A.A. Munoz, Wallans T. P. dos Santos, Amanda B. Lima |
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| Rok vydání: | 2013 |
| Předmět: |
Detection limit
Boron doped diamond Chromatography Chemistry Mechanical Engineering Analytical chemistry Diamond General Chemistry engineering.material Amperometry Electronic Optical and Magnetic Materials Waste generation Electrode Materials Chemistry engineering medicine Multiple pulse Electrical and Electronic Engineering Nimesulide medicine.drug |
| Zdroj: | Diamond and Related Materials. 39:41-46 |
| ISSN: | 0925-9635 |
| DOI: | 10.1016/j.diamond.2013.07.010 |
| Popis: | A fast and simple procedure for simultaneous determination of nimesulide and paracetamol (acetaminophen) was carried out by batch injection analysis with multiple pulse amperometric detection (BIA-MPA). The purpose is achieved with a unique and simple injection of a sample aliquot (150 μL) onto the unmodified boron-doped diamond (BDD) electrode immersed in a BIA system. The analytical characteristics of our proposed method include elevated analytical frequency (up to 46 injections per hour), high stability (RSD n = 12), low detection limits (0.293 and 0.297 mg L − 1 for paracetamol and nimesulide, respectively) and minimal waste generation. The proposed method presented similar results to those obtained by liquid chromatography at a 95% confidence level. |
| Databáze: | OpenAIRE |
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